Basenji Companions

Devoted to Basenjis as Pets

Fanconi Protocol Update

Updates from Steve Gonto, M.M.SC., Ph.D. – 9/12/16:

RECENT FINDINGS REGARDING GLUCOSE LOSS IN FANCONI SYNDROME: We have recently observed through EARLY “baseline blood gasses” on genetically “positive” tested dogs, that bicarbonate loss can happen YEARS before glucose loss. In short, glucose loss was never seen earlier than three years of age, and we assumed GENETIC Fanconi did not onset earlier, either. This proved to be WRONG. While some dogs do spill bicarbonate and, indeed, NEVER spill glucose, it doesn’t matter, as we now know glucose is a LATE disease indicator, NOT an early catch device by any means. We have seen significant bicarbonate loss in dogs as young as six months old. Treating early, and correcting the acid base imbalance, at least in the few cases thus caught this early, have so far resulted in incredible disease stability and no loss of glucose ever being seen in several of these dogs. As with ANY disease, the earlier caught the better the results.

GENERAL GUIDELINES FOR BASENIS LABELED “AFFLICTED” ON THE FANCONI GENETIC TEST: A venous blood gas should be done immediately upon getting that news, regardless of the Basenji’s age. If the venous blood gas shows the dog losing bicarbonate (minus Base Excess (B.E.)), and/or has a low HCO3 level (bicarbonate), then treatment should begin right away. If the venous blood gas is normal (Base Excess of about “0”, and an HCO3 of 23 or 24), I would recommend doing a repeat Venous Blood Gas every four months (three times a year), as well as urine strip testing every week or two, so as to try not to miss anything…until such time as the Fanconi gene actually activates.

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This entry was posted on September 23, 2016 by in Fanconi Syndrome, Health and Safety.
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